Cell‐based therapies for degenerative diseases of the musculature remain on the verge of feasibility. Myogenic cells are relatively abundant, accessible, and typically harbor significant proliferative potential ex vivo. However, their use for therapeutic intervention is limited due to several critical aspects of their complex biology. Recent insights based on mouse models have advanced our understanding of the molecular mechanisms controlling the function of myogenic progenitors significantly. Moreover, the discovery of atypical myogenic cell types with the ability to cross the blood‐muscle (...) barrier has opened exciting new therapeutic avenues. In this paper, we outline the major problems that are currently associated with the manipulation of myogenic cells and discuss promising strategies to overcome these obstacles. (shrink)

The term 'Taoism of Clarified Tenuity' designates a new branch of religious Taoism developed since the 13/14th century by priests of the long-established Heavenly Masters Taoism. They claimed to continue Taoist exorcist traditions that since the Sung-period especially flourished because emperor Sung Hui-tsung (r. 1100?1126) appreciated the exorcism of 'Taoism of the Divine Empyrean' and 'Five Thunders rituals'. The purpose of the exorcist rituals was the expulsion of demoniac molestations, relief from droughts and inundations, and the healing of illnesses. Outstanding (...) priests rationalized the exorcist practice, using theories of a meditative self-cultivation which peaked in the transformation into a Thunder divinity. The priest adopted a divine 'alter ego' for the time of the ritual. 'Taoism of Clarified Tenuity' developed on the basis of these traditions and embraced regionally different religious habits. It adopted and adapted older cults, partly including Buddhist-Tantric practices. Leading priests of 'Clarified Tenuity' presented theoretical essays, discussing the requirements of the personal cultivation of the Taoist to be a worthy performer of exorcism who was entitled to write and use amulets. The amulet was the essential ritual tool. However, the amulets of 'Clarified Tenuity' were remarkably different from the older 'Thunder' amulets of the Sung era. Also, the new branch adopted different attitudes concerning ritual practices such as the transformation into a divinity.0The book features developments of the more recent Taoist history and presents content and intention of 'Taoism of Clarified Tenuity'. The selected canonical texts also show that the priests of 'Clarified Tenuity' insisted on a clear distinction between exorcism in Heavenly Masters Taoism and shamanism that they disavowed. The book presents and analyses several 'Great Rituals' of 'Clarified Tenuity' and features elements of religious Taoism that today can still be traced. (shrink)

Machine generated contents note: Part I. Introduction: 1. Personal epistemology in the classroom: a welcome and guide for the reader Florian C. Feucht and Lisa D. Bendixen; Part II. Frameworks and Conceptual Issues: 2. Manifestations of an epistemological belief system in pre-k to 12 classrooms Marlene Schommer-Aikins, Mary Bird, and Linda Bakken; 3. Epistemic climates in elementary classrooms Florian C. Feucht; 4. The integrative model of personal epistemology development: theoretical underpinnings and implications for education Deanna C. Rule and (...) Lisa D. Bendixen; 5. An epistemic framework for scientific reasoning in informal contexts Fang-Ying Yang and Chin-Chung Tsai; Appendices; 6. Who knows what and who can we believe? Epistemological beliefs are beliefs about knowledge (mostly) to be attained from others Rainer Bromme, Dorothe Kienhues, and Torsten Porsch; Part III. Students' Personal Epistemology, its Development, and Relation to Learning: 7. Stalking young persons' changing beliefs about belief Michael J. Chandler and Travis Proulx; 8. Epistemological development in very young knowers Leah K. Wildenger, Barbara K. Hofer, and Jean E. Burr; 9. Beliefs about knowledge and revision of knowledge: on the importance of epistemic beliefs for intentional conceptual change in elementary and middle school students Lucia Mason; 10. The reflexive relation between students' mathematics-related beliefs and the mathematics classroom culture Erik De Corte, Peter Op 't Eynde, Fien Depaepe, and Lieven Verschaffel; 11. Examining the influence of epistemic beliefs and goal orientations on the academic performance of adolescent students enrolled in high-poverty, high-minority schools P. Karen Murphy, Michelle M. Buehl, Jill A. Zeruth, Maeghan N. Edwards, Joyce F. Long, and Shinichi Monoi; 12. Using cognitive interviewing to explore elementary and secondary school students' epistemic and ontological cognition Jeffrey A. Greene, Judith Torney-Purta, Roger Azevedo, and Jane Robertson; Part IV. Teachers' Personal Epistemology and its Impact on Classroom Teaching: 13. Epistemological resources and framing: a cognitive framework for helping teachers interpret and respond to their students' epistemologies Andrew Elby and David Hammer; 14. The effects of teachers' beliefs on elementary students' beliefs, motivation, and achievement in mathematics Krista R. Muis and Michael J. Foy; Appendices; 15. Teachers' articulation of beliefs about teaching knowledge: conceptualizing a belief framework Helenrose Fives and Michelle M. Buehl; Appendices; 16. Beyond epistemology: assessing teachers' epistemological and ontological world views Lori Olafson and Gregory Schraw; Part V. Conclusion: 17. Personal epistemology in the classroom: what does research and theory tell us and where do we need to go next? Lisa D. Bendixen and Florian C. Feucht. (shrink)

© 2016 Regents of the University of California.The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous (...) tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group. The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. (shrink)

Schon 1926 prägte der protestantische Theologe Fritz Jahr (1895-1953) aus Halle (Saale) den Begriff Bioethik. Der von Jahr vorgeschlagene bioethische Imperativ lautet dabei: «Achte jedes Lebewesen grundsätzlich als einen Selbstzweck und behandle es nach Möglichkeit als solchen!» Dieser Band untersucht die Perspektiven von Jahrs Thesen.

Psychiatrie und Psychotherapie sind Bereiche medizinischer Praxis, die in besonderer Weise ethische Fragen aufwerfen. Die Beiträge des Bandes hierzu werden durch zwei übersetzte Beiträge des polnischen Psychiaters Antoni Kępiński (1918-1972) erweitert. Diese eröffnen neue Perspektiven in der Diskussion um ethische Fragen in der Psychiatrie.

This article explores managers’ ethical reasoning for behaviors in price negotiations using evidence from 15 in-depth interviews conducted with sales and purchasing representatives in the chemical industry in Germany. Applying transaction cost economics, we find that negotiators in commoditized market-like exchanges either refer to deontological norms such as not to lie, or they neglect a role for ethics, arguing that distributive negotiation is per se opportunistic. In contrast, exchanges of products with higher asset specificity lead to stronger informational integration which (...) is supported with teleological justifications. Some negotiators use teleological justification to build business on trust rather than on economic safeguards as their firm norms would require. For negotiators, our results suggest considering institutional context and adjusting ethical reasoning to the negotiation situation. Firms need to recognize and find ways to address the potential conflicts of their internal norms with their frontline managers’ attempts to act in the firms’ best economic and ethical interests. (shrink)

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

S'il y a sens à parler d'un problème du réel, c'est du point de vue d'une réflexivité qui pose le concept même de réel. L'intérêt de la phénoménologie est de reconduire à la structure de cette réflexivité au sein de l'expérience. Le concret phénoménologique ne se révèle pas seulement dans la description (si subtile et attentive soit-elle), mais dans l'explicitation de la description. Il faut donc coordonner ces deux dimensions, la tension phénoménologique vers le concret et la tension réflexive dégageant (...) ce même concret comme concret en l'analysant dans sa relation au discours qui l'élabore. C'est l'articulation de ces deux dimensions que nous caractérisons de démarche transcendantale. Tel est donc le discours philosophique transcendantal : il réfléchit ses propres conditions d'effectuation et celles de ce qu'il déploie. Cette transcendantalité s'exprime à travers la mise à jour d'un réseau de coimplications ; une dimension de l'expérience se révèle par rapport à une autre, dont la mise au clair renvoie à son tour à d'autres types de structures qui ne prennent elles-mêmes sens qu'au regard du processus de pensée qui revient à les poser. A travers l'analyse de corpus, husserliens d'abord, puis heideggériens, merleau-pontyens, richiriens, etc., cet ouvrage tend à dégager une telle logique transcendantale pour situer les décisions fondamentales de ces philosophies dans un espace problématique, et à mieux comprendre ce qui en motive chaque fois le geste. Pour conclure, suit un exposé plus détaillé des traits caractéristiques d'un tel transcendantalisme dynamique. (shrink)

À quoi les philosophes sont-ils bons ? Faire de la philosophie rend-il meilleur ? Les jugements esthétiques gardent-ils encore quelque secret, ou bien Kant a-t-il tout dit sur la question ? La culture et le statut socio-économique de votre professeur de philosophie a-t-il une influence sur ses options philosophiques ? Pourquoi avons-nous l'impression que la pensée ne saurait être un état de notre cerveau ? Que nous ne serions pas libres si nous n'étions qu'un tas de neurone ? C'est pour (...) répondre à ces questions (et à beaucoup d'autres) que philosophes et psychologues se sont alliés sous la bannière de la toute nouvelle « philosophie expérimentale ». Il s'agit de faire un peu de lumière sur ce qui se passe vraiment dans notre tête lorsque nous faisons de la philosophie et d'interroger l'origine de nos certitudes philosophiques. (shrink)

Background: The COVID-19 crisis has had a considerable mental health impact on healthcare workers. High levels of psychological distress are expected to have a significant impact on healthcare systems, warranting the need for evidence-based psychological interventions targeting stress and fostering resilience in this population. Online cognitive behavioral therapy has proved to be effective in targeting stress and promoting resilience. However, online CBT programs targeting stress in healthcare workers are lacking.Objective: The aim of our study is to evaluate the feasibility and (...) acceptability of an internet-based CBT intervention, the My Health Too program we developed during the first COVID-19 epidemic peak in France.Methods: We recruited 10 participants among Alsace region hospital staff during the first peak of the pandemic in France. They were given 1 week to test the website and were then asked to answer an internet survey and a semi-structured phone interview.Results: We conducted a thematic analysis of the content from the phone interviews. Major themes were identified, discussed and coded: the technical aspects, the content of the website and its impact on participants’ emotions and everyday life. Overall, the participants reported finding the website easy to use and interactive. They described the resources as easy to understand, readily usable, and useful in inducing calm and in helping them practice self-compassion.Conclusion: Our results suggest that the My Health Too online CBT program is highly feasible and acceptable to healthcare workers during the highly stressful times of the pandemic peak. The feedback provided helped to improve the program whose efficacy is to be tested. (shrink)

A recent no-go theorem (Frauchiger and Renner in Nat Commun 9(1):3711, 2018) establishes a contradiction from a specific application of quantum theory to a multi- agent setting. The proof of this theorem relies heavily on notions such as ‘knows’ or ‘is certain that’. This has stimulated an analysis of the theorem by Nurgalieva and del Rio (in: Selinger P, Chiribella G (eds) Proceedings of the 15th international conference on quantum physics and logic (QPL 2018). EPTCS 287, Open Publishing Association, Waterloo, (...) 2018), in which they claim that it shows the “[i]nadequacy of modal logic in quantum settings” (ibid.). In this paper, we will offer a significantly extended and refined reconstruction of the theorem in multi-agent modal logic. We will then show that a thorough reconstruction of the proof as given by Frauchiger and Renner requires the reflexivity of access relations (system T). However, a stronger theorem is possible that already follows in serial frames, and hence also holds in systems of doxastic logic (such as KD45). After proving this, we will discuss the general implications for different interpretations of quantum probabilities as well as several options for dealing with the result. (shrink)

An effective formalism is developed to handle decaying two-state systems. Herewith, observables of such systems can be described by a single operator in the Heisenberg picture. This allows for using the usual framework in quantum information theory and, hence, to enlighten the quantum features of such systems compared to non-decaying systems. We apply it to systems in high energy physics, i.e. to oscillating meson–antimeson systems. In particular, we discuss the entropic Heisenberg uncertainty relation for observables measured at different times at (...) accelerator facilities including the effect of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$\mathcal{CP}$\end{document} violation, i.e. the imbalance of matter and antimatter. An operator-form of Bell inequalities for systems in high energy physics is presented, i.e. a Bell-witness operator, which allows for simple analysis of unstable systems. (shrink)

t. 1. "Myśl i rzeczywistość" i inne pisma filozofizne.

La médiation en droit public a, jusqu’à récemment, revêtu un caractère sectoriel, cantonnée à des domaines tout à fait spécifiques de l’action publique. Face à l’accroissement considérable de demande de justice administrative, il a fallu développer des outils de règlement non juridictionnel des litiges administratifs. C’est là qu’est intervenue la loi du 18 novembre 2016 de modernisation de la Justice du xxi e siècle – dite loi Justice 21.

Il s’agit dans cet article de proposer une interprétation du projet logique à travers une discussion entre Hegel et Frege. Au-delà des divergences bien connues concernant, entre autres, la formalisation du langage et le rapport aux mathématiques, et après avoir souligné quelques points de convergences parfois remarqués, notamment la critique du psychologisme, nous voulons montrer ici comment la logique se construit, et comment cette construction implique une certaine productivité de la forme logique. Le fait que la forme logique ne puisse (...) pas être abordée de manière immédiate, dans une évidence, conduit à une conception de celle-ci comme développement. Derrière cette présentation « organique » de la logique se joue en réalité une certaine compréhension de la forme dans laquelle celle-ci se produit elle-même dans son explicitation. Cette exigence d’autonomie est comprise à partir d’une analyse, chez Frege, de l’autonomie du nombre. Mais la réponse hégélienne sur le statut de celui-ci nous permet de souligner la contradiction que le nombre abrite. C’est à ce titre que nous pouvons rendre compte, de manière plus détaillée, non seulement du processus d’élaboration de la logique, mais également de la production des contenus : en comprenant le rapport réflexif de la forme comme instauration de la contradiction. (shrink)

t. 1. "Myśl i rzeczywistość" i inne pisma filozofizne.

Descartes a choisi, pour conclure les Méditations métaphysiques, de revenir sur une thèse majeure : la distinction réelle entre l’esprit et le corps. C’est aussi l’occasion pour lui de critiquer, à mots à peine couverts, la conception scolastique de la pesanteur. Ce texte rarement commenté a néanmoins été discuté par trois des plus grands lecteurs de Descartes (Gilson, Gouhier et Garber) qui s’accordent à y voir une charge contre les lointains disciples d’Aristote, même si aucune cible n’est explicitement mentionnée. Une (...) analyse minutieuse du dixième point des Sixièmes Réponses, en particulier de la page consacrée à la pesanteur, met aussi en évidence une liberté de langage déroutante, qui permet à Descartes de parler de l’esprit comme d’une qualité, de le dire ensuite étendu, et d’affirmer enfin qu’il faut penser pour se diriger vers un but déterminé. (shrink)

We prove a generalization of Alex Heller's existence theorem for recursion categories; this generalization was suggested by work of Di Paola and Montagna on syntactic P-recursion categories arising from consistent extensions of Peano Arithmetic, and by the examples of recursion categories of coalgebras. Let B=BX be a uniformly generated isotypical B#-subcategory of an iteration category C, where X is an isotypical object of C. We give calculations for the existence of a weak Turing morphism in the Turing completion Tur of (...) B when C is separated; i.e., when connected domains in C are jointly epimorphic. Our proof generalizes as follows. Let D be a separated iteration category and let L : C → D be an iteration functor; i.e., a functor which preserves domains, coproducts, zero morphisms and the iteration operator; it is crucial for the generalization that an iteration functor need not preserve products. If L is faithful, then Tur is a recursion category. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Un seul coup de crayon sur une feuille de papier, et tout l'espace s'ébranle : c'est la force du premier trait sur la toile vierge, c'est l'alif à l'origine de l'alphabet, c'est l'écriture se déployant dans les méandres de l'encre. Projection en même temps qu'inscription de la lumière sur une surface, de préférence plane et claire, l'ombre est la trace du vivant sur terre. A peine l'a-t-on cernée d'un contour que l'absent qui s'y est réfugié reprend forme, retrouve son identité, (...) et que la mémoire se met à agir. Dessins, estampes, photographies sont des moyens de retenir - chacun à leur manière, et chacun à leur rythme - ces brèves manifestations de l'existant. Florian Rodari s'interroge dans ces pages sur la volontaire et contraignante limitation au couple noir/blanc, dualité splendide de l'encre et du papier en vue d'obtenir - hors tout recours à la couleur - des images capables de satisfaire pleinement le regard. Sont réunis dans cet ouvrage un certain nombre de ses essais consacrés à des artistes aussi divers que Rembrandt, Victor Hugo, Henri Michaux, Jacques Henri Lartigue, Balthasar Burkhard ou Georg Baselitz. (shrink)

In Theologie und Wissenschaft bei Petrus Aureoli, Florian Wöller offers an account of the theories of science and of theology as they emerge from Peter Auriol's (c. 1280-1322) commentaries on the Sentences.

We present the results of four experiments concerning the evaluation people make of sentences involving “many”, showing that two sentences of the form “many As are Bs” vs. “many As are Cs” need not be equivalent when evaluated relative to a background in which B and C have the same cardinality and proportion to A, but in which B and C are predicates with opposite semantic and affective values. The data provide evidence that subjects lower the standard relevant to ascribe (...) “many” for the more negative predicate, and that judgments involving “many” are sensitive to moral considerations, namely to expectations involving a representation of the desirability as opposed to the mere probability of an outcome. We relate the results to similar semantic asymmetries discussed in the psychological literature, in particular to the Knobe effect and to framing effects. (shrink)

In 1978 and 1979 around 6.770 women in the GDR were infected with the hepatitis C virus after they had received a contaminated Anti-D-Immunprophylaxis. This prophylaxis was used after delivery, abortion or miscarriage. Until September 1979 2.769 women came down with Hepatitis. The reaction of the state showed how closely medicine and politics were linked in the GDR and what kind of influence governmental decisions had on medical action. The state wanted to keep everything as a secret. The producer of (...) the Anti-D-Immunglobulin in the GDR was sentenced as a pawn sacrifice in a non-public trial. The Ministry of State Security was also involved. Many of the infected women were traumatized by not being informed what had happened and had to fight for recognition and compensation until today. (shrink)

We explore the connections between Dickson’s lemma and weak Ramsey theory. We show that a weak version of the Paris–Harrington principle for pairs in c colors and miniaturized Dickson’s lemma for c-tuples are equivalent over \. Furthermore, we look at a cascade of consequences for several variants of weak Ramsey’s theorem.

Despite the positive effects of including patients’ preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar (...) to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP. (shrink)

The philosophical and exegetical oeuvre, biography and legacy of the Jewish-Italian Renaissance Rabbi Obadiah Sforno (c. 1475–1550) are revisited for the first time by international scholars presenting in-depth studies on the thoughts of a man “between two worlds”.

Mutations in the CEBPA gene are present in 10–15% of acute myeloid leukemia (AML) patients. The most frequent type of mutations leads to the expression of an N‐terminally truncated variant of the transcription factor CCAAT/enhancer‐binding protein alpha (C/EBPα), termed p30. While initial reports proposed that p30 represents a dominant‐negative version of the wild‐type C/EBPα protein, other studies show that p30 retains the capacity to actively regulate gene expression. Recent global transcriptomic and epigenomic analyses have advanced the understanding of the distinct (...) roles of the p30 isoform in leukemogenesis. This review outlines direct and indirect effects of the C/EBPα p30 variant on oncogenic transformation of hematopoietic progenitor cells and discusses how studies of N‐terminal CEBPA mutations in AML can be extrapolated to identify novel gain‐of‐function features in oncoproteins that arise from recurrent truncating mutations in transcription factors. (shrink)

Responding to recent concerns about the reliability of the published literature in psychology and other disciplines, we formed the X-Phi Replicability Project to estimate the reproducibility of experimental philosophy. Drawing on a representative sample of 40 x-phi studies published between 2003 and 2015, we enlisted 20 research teams across 8 countries to conduct a high-quality replication of each study in order to compare the results to the original published findings. We found that x-phi studies – as represented in our sample (...) – successfully replicated about 70% of the time. We discuss possible reasons for this relatively high replication rate in the field of experimental philosophy and offer suggestions for best research practices going forward. (shrink)